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Compare antibodies lab reagents for research
Suppliers for Lab ELISAs
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Our used monoclonals in Pubmed.
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Compare Pcr lab reagents for research
Suppliers for Lab rec.
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Our used monoclonals in Pubmed.
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Hologic Panther Fusion NATtrol
The expanding menu of Panther Fusion assays on the Panther Fusion system continues the legacy of testing precision and total lab automation that first began with the fully automated Panther system. Now, the flexibility of polymerase chain reaction (PCR) joins the power of transcription-mediated amplification (TMA) on the Panther Fusion system for multiple valuable chemistries on a single platform. These latest releases expand our diagnostic menu and consolidate testing to aid healthcare providers in diagnoses and maximize potential in the laboratory.
Leverage the benefits of the fully automated Panther Fusion system
The Panther Fusion system represents the latest innovation in Hologic diagnostic precision and automation. The Panther Fusion Respiratory assays leverage the benefits of the system as a whole, in addition to the assay-specific benefits.
Features include:
- The combined flexibility of PCR and TMA
- True sample-to-result automation
- The ability to run only necessary assays and reduce expenses from unnecessary testing
- Total nucleic acid extraction, with multiple tests from a single sample and multiplexing
- Unit dose lyophilized reagents, which eliminate reagent waste and the need for manual reagent preparation
- The ability to hold up to 28 cartridges, each with 12 reactions per cartridge for a total of 336 tests
- Kits that can be reloaded as they are consumed without pausing testing
The Panther Fusion Respiratory assays
The Panther Fusion Respiratory assays for syndromic respiratory testing are the premier set of assays on the Panther Fusion system. You now can provide truly personalized patient testing with qualitative detection and differentiation of the most common respiratory viruses using a single patient sample. Each Panther Fusion Respiratory assay can be processed independently or simultaneously with other Panther Fusion and Aptima assays.
The Panther Fusion Respiratory menu leverages a legacy of expertise in respiratory viral molecular diagnostics from Hologic that began over a decade ago with the Prodesse Plus Series of respiratory assays.
Three respiratory assays comprise the IVD respiratory testing menu on the fully automated Panther Fusion system. Each is a multiplex, real-time PCR in vitro diagnostic test. They isolate and purify nucleic acids from nasopharyngeal (NP) swab specimens obtained from patients who are symptomatic for respiratory tract infection. All 3 assays can be run from a single patient specimen loaded into the Panther Fusion system.
The Panther Fusion assays provide the flexibility to run patient-specific targets, allowing for personalized patient testing and better cost control in your lab.
- The Panther Fusion Flu A/B/RSV assay – Qualitative detection and differentiation of influenza A virus, influenza B virus and respiratory syncytial virus
- The Panther Fusion AdV/hMPV/RV assay – Qualitative detection and differentiation of adenovirus, human metapneumovirus and rhinovirus
- The Panther Fusion Paraflu assay – Qualitative detection and differentiation of parainfluenza 1 virus, parainfluenza 2 virus, parainfluenza 3 virus, and parainfluenza 4 virus
Panther Fusion GBS assay
The Panther Fusion GBS assay joins the expanding molecular testing menu on the Panther Fusion system. This assay detects the gram-positive bacterium Streptococcus agalactiae (GBS) in pregnant women and so providers can prevent its transmission to their babies.4 GBS has serious long-term health consequences, including death, in newborns.
A Sensitive Assay for a Distinct Threat
This assay features world-class performance and sensitivity, answering a crucial need for GBS detection. GBS is a serious and sometimes fatal infection that is passed to infants during birth.5 GBS is a leading cause of early-onset neonatal sepsis in the United States, and it also can cause pneumonia and meningitis.5 Antibiotic prophylaxis can reduce transmission of GBS to babies when administered properly. The Panther Fusion GBS assay helps providers diagnose GBS in mothers so they can confidently determine if intrapartum prophylaxis is needed.
Intuitive Design for Real-World Need
The CDC states that accurate results are more important than rapid turnaround time for antenatal screening.5 When providers have diagnostic tools with excellent sensitivity and performance, they can deliver the highest level of care. The Panther Fusion GBS assay is a real-time PCR assay for antepartum testing with enriched vaginal and rectal swabs. It features dual-target detection of Cfb and SIP genes and 100% clinical sensitivity.4
True Flexibility and Full Automation
Run-on the Panther Fusion system, this assay offers the benefits of Panther Fusion automation, high-throughput flexibility, and ease of use, allowing for high-volume GBS testing in reference laboratories and hospitals. It may be processed, free from batching on the Panther Fusion system with other Aptima and Panther Fusion assays for women’s health, virology, respiratory, and sexually transmitted infections.
TYPES OF IMMUNITY
Immunoassays are a combination of biochemical techniques used to identify, and in other cases quantifiable, a certain molecular molecule present in a biological sample. The characteristic foundation which includes the types of immunity is that all of them are based on a specific anti-antigen reaction .
In this case, the 9 types of immunologicals that reveal more frequently in the laboratories of investigation should be reviewed.
TYPES OF IMMUNITY
1.- WESTERN BLOT (WB)
A Western Blot technician, the proteins presented in a determined biological sample are separated in the function of their median electrophoresis, to be transferred to a membrane and tissues with a specific anticancer.
With this technique, in order to detect the protein of interest, it is possible to determine its own, confirming whether there are post-translational modifications or comparing their concentration in different samples, between others.
2.- IMMUNOPRECIPITATION (IP)
Immunoprecipitation is used to determine the protein of the components present in a sample, taking into account the precipitation of anti-antigen compounds.
In addition to the detection and quantification of proteins, their applications are very different, including the determination of the molecular weight of a given antigen, the study of interactions between proteins or the monitoring of post-translational modifications.
3.- RADIOINMUNOENSAYO (RIA)
This immunoassay uses radioactive isotopes to mark the anti-antigen complex. It is important to follow the reading of radiation to detect these complexes and to confirm and / or quantify the presence of protein of interest in the sample.
One of the sales of Radioinmunoensayo is a very sensitive technique , which makes it possible to detect proteins that are found in other concentrations in the sample. Without embargo, it is also due to a practical importer, and it is a potential pilgrim that works with radioactive material.
4.- ELISA (ENZYME ENZYMES)
Of the different types of immunoassays, ELISA is one of the most popular and of the most frequently used research laboratories in their implementation, versatility and other sensitivities and specificities.
It is essential in the use of enzymes that allow the detection of anti-antigen unions (and therefore the presence of a certain antigen in the sample) to catalyze a colorimetric reaction to add the corresponding correspondence.
5.- CLIA (CHEMICAL IMMUNOSUPPRESSANTS)
The CLIA chemimuminescence tests, based on ELISA, differ in the case of this anti-antigen union measure, in addition to the generation of fluorescence generating a chemical reaction.
The CLIA examines the unconventional need for specific equipment to read the fluorescence, but in contrast to the sale of the significantly more sensible ELISAs.
6.- IMMUNOFLUORESCENCE (IF)
In immunofluorescence tests, the detection of the antigen of interest within the Union and of the specific anti-dumping shall be indicated by the use of fluorophores.
7.- IMMUNOHISTOCHEMISTRY (IHC)
These include a combination of immunological, biochemical and histological techniques for the detection of an antigen present in a section measuring the use of specific anti-dumping measures. Admittedly, it is possible to visualize the distribution and location of this antigen inside the studio.
8.- IMMUNOCYTOCHEMISTRY (ICC)
It is a technique with a foundation similar to the immunological chemistry, so that in this case, the immunocitochemistry allows the detection of an antigen inside a cell.
Thus, the IHC, as the ICC, is subject to less than any sensitivities to an ELISA or a Western blot, which may allow the antigen to be recorded in the context of a cell or one intact, not necessarily the need for an alarm.
9.- CITOMETRÍA DE FLUJO (FC)
Inside the different types of immunizations, it is one of the most complete. The flow cytometry is a method of dispersing and reflecting the light from the laser to analyze and analyze cells in suspension in the functioning of their physical-chemical characteristics.
TOP antibodies – AMACR (P504S) (clone 13H4) – rabbit monoclonal antibody
AMACR (P504S) (clone 13H4) – rabbit monoclonal antibody
Clone 13H4 – a classic that will not get bored
AMACR (P504S) is an essential enzyme in the β-oxidation of branched chain fatty acids. High expression of the AMACR protein (P504S) has been demonstrated in prostate adenocarcinoma. Positivity is lacking in normal tissue, prostate tissue or benign lesions. AMACR (P504S) expression has also been demonstrated in two premalignant prostate lesions: high grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. The use of AMACR (P504S) as a positive marker along with basal cell staining (CK HMW or P63) as a negative marker may help to confirm the diagnosis of small-scale prostate cancer in a needle biopsy.
Positive control: kidney
Cellular localization: cytoplasmic
Human prostate cancer stained with anti-AMACR antibody using formalin-fixed peroxidase conjugate and DAB chromogen embedded in paraffin. Note the cytoplasmic and luminal peripheral staining of cancerous glands.